5-HT2C Receptors in the Pathophysiology of CNS Disease by Jose M. Palacios, Angel Pazos, Daniel Hoyer (auth.),

By Jose M. Palacios, Angel Pazos, Daniel Hoyer (auth.), Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo (eds.)

Research of 5-HT2c receptors stretches again twenty-five years, and whereas a lot of it's been efficient, the prior decade of analysis has been outstanding when it comes to either volume produced and insights received. it truly is hardly ever striking that 5-HT2c receptor examine has grown so fruitful, provided that it's a favorite primary serotonin receptor subtype extensively expressed in the significant and the peripheral frightened method and is believed to play an important function within the legislation of various behaviors. It has extra been proven by means of experimental and medical commentary that it can characterize a potential healing aim for the improvement of gear for a variety of significant worried approach issues. The time, for that reason, is greater than acceptable to provide the 1st ever evaluate of the study of 5-HT2c receptors. a part of the preferred and significant sequence, “The Receptors,” The 5-HT2c Receptor offers a radical replace of the practical prestige of the 5-HT2c receptor. It covers the molecular, mobile, anatomical, biochemical and behavioral elements of this receptor to be able to spotlight its unique regulatory houses and the rising sensible value of constitutive job and RNA-editing in vivo. additionally, the ebook investigates the receptors’ healing strength in a number of diversified illnesses, taken care of separately in separate chapters, together with melancholy, drug abuse, schizophrenia, consuming issues, Parkinson’s ailment, Prader-Willi Syndrome, Alzheimer’s illness and epilepsy. whereas no longer exhaustive, this article is a crucial software in knowing the earlier and encouraging the way forward for interdisciplinary study at the 5-HT2c receptor.

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Additional info for 5-HT2C Receptors in the Pathophysiology of CNS Disease

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As in the rodent brain, there is in general a good correlation between mRNA and binding sites in human and monkey brains with the exceptions identified above. Some of these exceptions are now discussed in relationship to the cellular localization of these receptors. 4 Phenotype of Cells Expressing 5-HT2C Receptors The widespread distribution of 5-HT2C receptors in the brain of the mammalian species studied until now suggests, as is the case for other neurotransmitter receptors, that 5-HT2C receptors are expressed by neurons with different neurotransmitter phenotypes.

Around 50% of the neurons expressing 5-HT2C receptor immunoreactivity in the prelimbic region of the medial prefrontal cortex also expressed GAD67 immunoreactivity (Liu et al. 2007), a marker of GABAergic interneurons. We have detected abundant expression of 5-HT2C receptor mRNA in layer V cells of the mouse cingulate cortex that were not GABAergic. 2. 3 5-HT2C Receptors and Cholinergic Neurons In our studies on the distribution of 5-HT2C receptor mRNA in the Macaca brain (López-Giménez et al.

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